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Condition

Male-factor infertility

Male-factor infertility means a difficulty conceiving that is related, fully or partly, to sperm. It is common — ASRM estimates a male factor is involved in around half of couples who have difficulty conceiving — and is assessed mainly through semen analysis and a clinical review.

About male-factor infertility

Male-factor infertility refers to sperm-related reasons for difficulty conceiving. It is common — the WHO notes about 1 in 6 people of reproductive age experience infertility, and ASRM estimates a male factor is the sole cause in around a fifth of affected couples and a contributing factor in a further third, so it is involved in roughly half of cases. It often has no outward signs, so it is usually identified through testing rather than symptoms.

How it is assessed

The main test is a semen analysis, which looks at the number, movement, and shape of sperm, among other measures. Results are compared with WHO reference values — but these are lower reference limits derived from men whose partners conceived naturally, not a pass/fail line, so a result below a limit is not an automatic diagnosis. Because sperm quality naturally varies, an abnormal result is usually repeated, often after about three months, before conclusions are drawn. A clinician interprets results alongside your history.

Options

Depending on the findings, options may include lifestyle changes to support semen quality, treating an underlying cause, and assisted conception such as IUI or ICSI as part of IVF. Care is individualised, and a specialist can explain what fits your situation.

Common signs (they vary between people)

  • Often there are no outward signs; it is usually identified through testing rather than symptoms
  • Sometimes linked to previous medical or surgical history
  • Lifestyle and environmental factors (such as smoking, heavy alcohol use, and obesity) can affect semen quality

How it is usually evaluated

  • Semen analysis, often repeated after about three months
  • Medical history and examination
  • Further specialist tests where indicated

Symptoms that need prompt attention

  • Testicular pain or a new lump should be checked promptly, though these are not fertility emergencies
Medical review complete
Written by
Sam Rivera · Health writer
Medically reviewed by
Dr Amir Hassan · Andrologist (medical reviewer)
Last reviewed
Next review due

Sources

  1. Low sperm countNHS · Published 26 January 2024 · Accessed 19 July 2026
  2. InfertilityNHS · Published 9 August 2023 · Accessed 19 July 2026
  3. Infertility fact sheetWorld Health Organization (WHO) · Published 28 November 2025 · Accessed 19 July 2026
  4. WHO laboratory manual for the examination and processing of human semen, 6th editionWorld Health Organization (WHO) · Published 27 July 2021 · Accessed 19 July 2026
  5. ReproductiveFacts.org patient resourcesAmerican Society for Reproductive Medicine (ASRM) · Accessed 19 July 2026

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